IWP-4
货号：
2650-1 基本售价：
1340.0 元 规格：
1mg
产品信息
概述| 货号 | 2650-1 |
| 描述 | IWP-4 is a potent inhibitor of Wnt production that blocks Wnt pathway activity in vitro (IC₅₀ = 25 nM). IWP-4 inactivates Porcupine (porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. At 5 μM, IWP-4 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin. IWP-4 has been used to induce cardiomyocyte differentiation from human pluripotent stem cells. |
性能| 供应商 | Biovision |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| CAS号 | 686772-17-8 |
| 外观 | Crystaline solid |
