| 货号 | 1472/100 |
| 别名 | 8,8'-[Carbonylbis[imino-3,1-phenylen |
| 供应商 | Tocris |
| 生物活性 | Non-selective P2 purinergic antagonist. Also blocks calmodulin binding to recognition sites and G protein coupling to G protein-coupled receptors. Increases open probability of ryanodine receptor (RyR) channels. Anticancer and antiviral agent. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 1429.15 |
| 分子式 | C51H34N6Na6O23S6 |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 10 mM in DMSO |
| CAS号 | 129-46-4 |
| 参考文献 | Hillet al (2004) Functional regulation of the cardiac ryanodine receptor by suramin and calmodulin involves multiple binding sites. Mol.Pharmacol. 65 1258. PMID: 15102954. Klingeret al (2001) Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sites. Biochem.J. 355 827. PMID: 11311147. Beindlet al (1996) Inhibition of receptor/G protein coupling by suramin analogues. Mol.Pharmacol. 50 415. PMID: 8700151. Charltonet al (1996) PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors. Br.J.Pharmacol. 118 704. PMID: 8762097. Voogdet al (1993) Recent research on the biological activity of suramin. Pharmacol.Rev. 45 177. PMID: 8396782. |