| 货号 | 2280/50 |
| 别名 | [6-Hydroxy-2-(4-hydroxyphenyl)benzo |
| 供应商 | Tocris |
| 生物活性 | Selective estrogen receptor modulator (SERM) that binds to ERα and ERβ, and tissue-dependently activates or blocks estrogen-induced transcription. Acts as an antiestrogen in breast and uterine tissue, but displays estrogen agonist activity in bone. In D12 rat hypothalamic cells, inhibits progesterone receptor induction by estrogen with an IC50 of 1 nM. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 510.04 |
| 分子式 | C28H27NO4S.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 84449-90-1 |
| 参考文献 | Todorova (2011) Tamoxifen and raloxifene suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake. Cancer Chemother. Pharmacol. 67 285. PMID: 20383709. Hibneret al (2004) Effects of raloxifene hydrochloride on endometrial cancer cells in vitro. Gynecologic Oncol. 93642. Bryant (2001) Mechanism of action and preclinical profile of raloxifene, a selective estrogen receptor modulator. Rev.Endocr.Metab.Disord. 2 129. PMID: 11704975. Fitzpatricket al (1999) Effect of estrogen agonists and antagonists on induction of progesterone receptor in a rat hypothalamic cell line. Endocrinology 140 3928. PMID: 10465261. |