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货号： bs-4222R-PE-Cy5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-4222R-PE-Cy5
- 英文名称
- Anti-PSME3/PE-Cy5
- 中文名称
- PE-Cy5标记的蛋白酶体激活因子PA28γ抗体
- 别 名
- PA28G; 11S regulator complex gamma subunit; 11S regulator complex subunit gamma; Activator of multicatalytic protease subunit 3; Ki antibody Ki antigen; Ki nuclear autoantigen; Ki, PA28 gamma; PA28 gamma; PA28gamma; Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); Proteasome (prosome, macropain) activator subunit 3; Proteasome activator 28 gamma; Proteasome activator 28 subunit gamma; Proteasome activator complex subunit 3; Proteasome activator subunit 3; PSME3; PSME3_HUMAN;
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 染色质和核信号 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 28kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PSME3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a donut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-TP53/p53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of TP53/p53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.
Database links:Entrez Gene: 420017Chicken
Entrez Gene: 740582Chimpanzee
Entrez Gene: 480512Dog
Entrez Gene: 101131213Gorilla
Entrez Gene: 10197Human
Entrez Gene: 19192Mouse
Entrez Gene: 100171504Orangutan
Entrez Gene: 397625Pig
Entrez Gene: 287716Rat
Entrez Gene: 494719 Xenopus laevis
Entrez Gene: 100124751 Xenopus tropicalis
Omim: 605129Human
SwissProt: Q5F3J5Chicken
SwissProt: P61289Human
SwissProt: P61290Mouse
SwissProt: Q5RFD3Orangutan
SwissProt: P61291Pig
Unigene: 152978Human
Unigene: 288477Mouse
Unigene: 198325Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.