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货号： bs-6702R-PE-Cy5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6702R-PE-Cy5
- 英文名称
- Anti-TRPC3/PE-Cy5
- 中文名称
- PE-Cy5标记的色氨酸相关蛋白3抗体
- 别 名
- Htrp 3; Htrp3; MGC124333; Mtrp3; Receptor activated cation channel TRP3v Short transient receptor potential channel 3; Transient receptor potential cation channel subfamily C member 3; Transient receptor potential channel 3; TRANSIENT RECEPTOR POTENTIAL DROSOPHILA HOMOLOG OF 3; Trp related protein 3; TRP3; TrpC3; Trrp3.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 神经生物学 信号转导 转录调节因子 结合蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 92kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TRPC3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
TRPC channels form the subfamily of channels in human most closely related to drosophila TRP channels. Structurally, this family shares a number of similar characteristics. At the proximal C-terminus of this sub-family is a TRP box motif containing the invariant EWKFAR sequence and between 3 and 4 ankyrin repeats near the N-terminus. These channels are non-selectively permeable to cations, with a selectivity of calcium over sodium variable among the different members. Many of TRPC channel subunits are able to coassemble.
Function:
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.
Subunit:
Interacts with TRPC1, ITPR1, ITPR3, MX1 and RNF24. Interacts with JPH2; the interaction is involved in maintaining Ca(2+) homeostasis in skeletal muscle and is mediated by JPH2 Ser-165 phosphorylation.
Subcellular Location:
Cell Membrane; multi-pass membrane protein
Tissue Specificity:
Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.
Similarity:
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily.
Contains 4 ANK repeats.
Database links:Entrez Gene: 7222 Human
Entrez Gene: 22065 Mouse
Entrez Gene: 60395 Rat
Omim: 602345 Human
SwissProt: Q13507 Human
SwissProt: Q9QZC1 Mouse
SwissProt: Q9JMI9 Rat
Unigene: 150981 Human
Unigene: 74363 Mouse
Unigene: 45385 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.