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货号： bs-7522R-PE-Cy5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7522R-PE-Cy5
- 英文名称
- Anti-TXA2R/PE-Cy5
- 中文名称
- PE-Cy5标记的血栓素A2受体抗体
- 别 名
- Thromboxane A2 receptor; Prostanoid TP receptor; TBXA2R; TP receptor; TXA2 R; TXA2R; TA2R_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞生物 信号转导 细胞膜受体 G蛋白偶联受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 38kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Thromboxane A2 receptor
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Thromboxane A2 receptor is a member of the G protein-coupled receptor superfamily. It performs an essential role in hemostasis by interacting with thromboxane A2 to induce platelet aggregation. Thromboxane A2 is an arachidonic acid metabolite produced by the action of thromboxane synthase on prostaglandin endoperoxide H(2) (PGH(2)), which results from the enzymatic transformation of arachidonic acid by the cyclooxygenases (COX-1 and COX-2). In humans Thromboxane A2 signals through two distinct Thromboxane A2 receptor isoforms which differ only in their C-terminal tails: alpha form (placenta) and beta form (endothelium). The interaction between Thromboxane A2 receptor and Thromboxane A2 is involved in the pathogenesis of numerous cardiovascular diseases such as atherosclerosis. Consequently, designing Thromboxane A2 receptor antagonists remains of great interest in cardiovascular medicine.
Function:
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.
Subunit:
Interacts with RPGRIP1L. Interacts with PSMA3. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2R cell surface expression.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:Entrez Gene: 6915 Human
Entrez Gene: 21390 Mouse
Entrez Gene: 24816 Rat
Omim: 188070 Human
SwissProt: P21731 Human
SwissProt: P30987 Mouse
SwissProt: P34978 Rat
Unigene: 442530 Human
Unigene: 4545 Mouse
Unigene: 44614 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.