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货号： bs-18931R-PE-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18931R-PE-Cy3
- 英文名称
- Anti-MIA40/PE-Cy3
- 中文名称
- PE-Cy3标记的MIA40蛋白抗体
- 别 名
- CHCHD4; Coiled coil helix coiled coil helix domain containing 4; Coiled coil helix coiled coil helix domain containing protein 4; Coiled-coil-helix-coiled-coil-helix domain-containing protein 4; FLJ31709; MIA40_HUMAN; Mitochondrial intermembrane space import and assembly 40 homolog; Mitochondrial intermembrane space import and assembly protein 40; TIMM40; Translocase of inner mitochondrial membrane 40 homolog.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 16kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MIA40
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005 [PubMed 16185709]).[supplied by OMIM, Mar 2008]
Function:
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Probably acts by forming a redox cycle with GFER/ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS.
Subcellular Location:
Mitochondrion intermembrane space.
Tissue Specificity:
Expressed in all tissues tested, suggesting an ubiquitous expression.
Post-translational modifications:
Forms intrachain disulfide bridges, but exists in different redox states.
Database links:Entrez Gene: 131474Human
Entrez Gene: 72170Mouse
Entrez Gene: 100361898Rat
Entrez Gene: 100364342Rat
Entrez Gene: 312559Rat
Entrez Gene: 445144Zebrafish
Omim: 611077Human
SwissProt: Q8N4Q1Human
SwissProt: Q8VEA4Mouse
SwissProt: Q5BJN5Rat
SwissProt: Q6DEI8Zebrafish
Unigene: 517815Human
Unigene: 41622Mouse
Unigene: 16427Rat
Unigene: 117015Zebrafish
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.