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货号： bs-18223R-PE-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18223R-PE-Cy3
- 英文名称
- Anti-LEPREL1/PE-Cy3
- 中文名称
- PE-Cy3标记的LEPREL1蛋白抗体
- 别 名
- 4832416N06; AW553532; Leprecan like 1; Leprecan-like protein 1; Leprel1; MCVD; MLAT4; Myxoid liposarcoma-associated protein 4; P3H2; P3H2_HUMAN; Prolyl 3 hydroxylase 3; Prolyl 3-hydroxylase 2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 神经生物学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 78kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human LEPREL1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. These enzymes play a critical role in collagen chain assembly, stability and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues. Mutations in this gene are associated with nonsyndromic severe myopia with cataract and vitreoretinal degeneration, and downregulation of this gene may play a role in breast cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Function:
Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly-sequences in collagens, especially types IV and V.
Subcellular Location:
Endoplasmic reticulum. Golgi apparatus.
Tissue Specificity:
Expressed in heart, placenta, lung, liver, skeletal muscle and kidney. Expression localized to the epithelia of bile ducts and to the sacroplasm of heart muscle and skeletal muscle. In the pancreas, localized to a subpopulation of Langerhans islet cells and in the salivary gland, expressed in acinar cells.
Similarity:
Belongs to the leprecan family.
Contains 1 Fe2OG dioxygenase domain.
Contains 4 TPR repeats.
Database links:Entrez Gene: 511799Cow
Entrez Gene: 478674Dog
Entrez Gene: 55214Human
Entrez Gene: 210530Mouse
Entrez Gene: 100520219Pig
Entrez Gene: 288016Rat
Omim: 610341Human
SwissProt: Q8IVL5Human
SwissProt: Q8CG71Mouse
SwissProt: Q4KLM6Rat
Unigene: 374191Human
Unigene: 483044Mouse
Unigene: 213595Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.