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货号： bs-3719R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-3719R-Cy7
- 英文名称
- Anti-Phospho-Talin (Ser425)/Cy7
- 中文名称
- Cy7标记的磷酸化踝蛋白抗体
- 别 名
- Talin 1 (phospho S425); p-Talin 1 (phospho S425); TLN 1; ILWEQ; Talin 1; Talin; TLN; TLN1; TLN1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 产品类型
- 磷酸化抗体
- 研究领域
- 肿瘤 免疫学 信号转导 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 280kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated Synthesised phosphopeptide derived from human Talin around the phosphorylation site of Ser425
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-270 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin. Talin and vinculin have been shown to interact with each other and both have been proposed to be involved in generating the transmembrane connection, between the extracellular matrix and the cytoskeleton, that occurs at adhesion plaques. At physiological ionic strength, talin is an elongate, flexible, monomeric protein with the ability to self-associate into dimers at higher protein concentrations.
Function:
Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
Subunit:
Binds with high affinity to VCL and with low affinity to integrins. Interacts with PTK2/FAK1. Interacts with PIP5K1C and NRAP. Interacts with LAYN. Interacts with SYNM.
Subcellular Location:
Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Colocalizes with LAYN at the membrane ruffles.
Similarity:
Contains 1 FERM domain.
Contains 1 I/LWEQ domain.
Database links:Entrez Gene: 395194 Chicken
Entrez Gene: 7094 Human
Entrez Gene: 21894 Mouse
Entrez Gene: 313494 Rat
Omim: 186745 Human
SwissProt: P54939 Chicken
SwissProt: Q9Y490 Human
SwissProt: P26039 Mouse
Unigene: 471014 Human
Unigene: 208601 Mouse
Unigene: 7715 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TALIN-踝蛋白。是重要的细胞骨架肌动蛋白结合蛋白，由两个270kDa的亚单位组成的反向平行的同源二聚体，与整合蛋白B尾部的结合诱导了整合蛋白胞外结构域构象的改变,起到了对整合蛋白的激活。