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货号： bs-3799R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-3799R-Cy7
- 英文名称
- Anti-KLK11/Cy7
- 中文名称
- Cy7标记的激肽释放酶11抗体
- 别 名
- Hippostasin; hK11; KLK 11; KLK-11; kallikrein 11; Kallikrein 11 isoform 1 preproprotein; Kallikrein 11 isoform 2 precursor; Kallikrein 11 precursor; kallikrein related peptidase 11; KLK 11; KLK11; Protease serine 20 trypsin like; Protease serine trypsin like; PRSS20; Serine protease 20; TLSP; Trypsin like protease; KLK11_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 25kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human KLK11
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Kallikrein 11 has two alternative splicing isoforms, known as the brain type and prostate type. Elevated serum levels of hK11 have been found in 70% of women with ovarian cancer and in 60% of men with prostate cancer. Analysis of this biomarker in serum may aid in the diagnosis and monitoring of ovarian and prostatic carcinoma.
Function:
Possible multifunctional protease. Efficiently cleaves bz-Phe-Arg-4-methylcoumaryl-7-amide, a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
Subcellular Location:
Isoform 1: Secreted.
Isoform 2: Golgi apparatus.
Tissue Specificity:
Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).
Post-translational modifications:
About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.
Similarity:
Belongs to the peptidase S1 family. Kallikrein subfamily.
Contains 1 peptidase S1 domain.
Database links:Entrez Gene: 11012 Human
Entrez Gene: 56538 Mouse
Omim: 604434 Human
SwissProt: Q9UBX7 Human
SwissProt: Q9QYN3 Mouse
Unigene: 57771 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.