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货号： bs-3820R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-3820R-Cy7
- 英文名称
- Anti-BAP135/TFII I/Cy7
- 中文名称
- Cy7标记的蛋白酪氨酸激酶BAP135抗体
- 别 名
- BAP 135; BAP135; Bruton tyrosine kinase associated protein 135; BTK associated protein 135; BTK associated protein 135kD; BTK associated protein; BTKAP 1; BTKAP1; DIWS; General transcription factor II i; GTF 2I; GTF2I; GTFII I; IB 291; IB291; SPIN; SRF Phox 1 interacting protein; SRF Phox1 interacting protein; Transcription factor II I; WBS; WBSCR 6; WBSCR6; Williams Beuren syndrome chromosome region 6; Williams Beuren syndrome chromosome region 6 protein.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 信号转导 转录调节因子 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 112kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human BAP135/TFII I
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
TFII I is a ubiquitously expressed multifunctional transcription factor with broad biological roles in transcription and signal transduction in a variety of cell types. It has been shown that TFII I can interact physically and functionally with Btk (Brutons tyrosine kinase), a hematopoietic non-receptor protein tyrosine kinase that is critical for B lymphocyte development.
Function:
Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.
Subcellular Location:
Cytoplasm. Nucleus. Colocalizes with BTK in the cytoplasm.
Tissue Specificity:
Ubiquitous. Isoform 1 is strongly expressed in fetal brain, weakly in adult brain, muscle, and lymphoblasts and is almost undetectable in other adult tissues, while the other isoforms are equally expressed in all adult tissues.
Post-translational modifications:
Transiently phosphorylated on tyrosine residues by BTK in response to B-cell receptor stimulation. Phosphorylation on Tyr-248 and Tyr-398, and perhaps, on Tyr-503 contributes to BTK-mediated transcriptional activation.Sumoylated.
DISEASE:
Note=GTF2I is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of GTF2I may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
Similarity:
Belongs to the TFII-I family.
Contains 6 GTF2I-like repeats.
Database links:Entrez Gene: 2969Human
Entrez Gene: 14886Mouse
Entrez Gene: 353256Rat
Omim: 601679Human
SwissProt: P78347Human
SwissProt: Q9ESZ8Mouse
SwissProt: Q5U2Y1Rat
Unigene: 647041Human
Unigene: 261570Mouse
Unigene: 412191Mouse
Unigene: 27575Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.