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货号： bs-3829R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-3829R-Cy7
- 英文名称
- Anti-Sorbitol Dehydrogenase/Cy7
- 中文名称
- Cy7标记的山梨醇脱氢酶抗体
- 别 名
- L iditol 2 dehydrogenase; SDH; SORD 1; SORD; SORD1. DHSO_HUMAN
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 免疫学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 38kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Sorbitol Dehydrogenase C-terminus
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme. SDH is expressed almost ubiquitously in all mammalian tissues. The enzyme has attracted considerable interest due to its implication in the development of diabetic complications as the polyol pathway is particularly active in hyperglycemic states. Although SORD is closely related to the class I long-chain alcohol dehydrogenases, it differs in substrate specificity, catalyzing polyols such as sorbitol and xylitol but having no activity towards primary alcohols.
Function:
Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm (By similarity).
Subunit:
Homotetramer.
Subcellular Location:
Mitochondrion membrane; Peripheral membrane protein. Cell projection, cilium, flagellum. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface (By similarity).
Tissue Specificity:
Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level).
Similarity:
Belongs to the zinc-containing alcohol dehydrogenase family.
Database links:Entrez Gene: 508954 Cow
Entrez Gene: 6652 Human
Entrez Gene: 20322 Mouse
Entrez Gene: 24788 Rat
Omim: 182500 Human
SwissProt: Q58D31 Cow
SwissProt: Q4R639 Cynomolgus Monkey
SwissProt: Q00796 Human
SwissProt: Q64442 Mouse
SwissProt: Q5R5F3 Orangutan
SwissProt: P27867 Rat
Unigene: 878 Human
Unigene: 371580 Mouse
Unigene: 11334 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.