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货号： bs-3891R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-3891R-Cy7
- 英文名称
- Anti-NOXA2/Cy7
- 中文名称
- Cy7标记的NADPH氧化酶活化蛋白1抗体
- 别 名
- NCF-2; Ncf2; Neutrophil NADPH oxidase factor 2; p67-phox; p67phox; neutrophil cytosol factor 2 isoform 1; neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2); NADPH oxidase activator 2; neutrophil cytosol factor 2; 67 kDa neutrophil oxidase factor; NCF2_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 58kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NOXA2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes neutrophil cytosolic factor 2, the67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Function:
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Subunit:
Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF4. Interacts (via the C-terminal SH3 domain) with NCF1 (via C-terminus). Interacts with SYTL1 and RAC1. May interact with NOXO1. Interacts with S100A8 and calprotectin (S100A8/9).
Subcellular Location:
Cytoplasm.
DISEASE:
Granulomatous disease, chronic, cytochrome-b-positive 2, autosomal recessive (CGD2) [MIM:233710]: A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.
Similarity:
Belongs to the NCF2/NOXA1 family. {ECO:0000305}.
Contains 1 PB1 domain.
Contains 2 SH3 domains.
Contains 3 TPR repeats.
Database links:Entrez Gene: 4688 Human
Entrez Gene: 17970 Mouse
Entrez Gene: 364018 Rat
Omim: 608515 Human
SwissProt: P19878 Human
SwissProt: O70145 Mouse
SwissProt: Q3U5S4 Mouse
SwissProt: A7E3N2 Rat
Unigene: 587558 Human
Unigene: 270307 Mouse
Unigene: 162331 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.