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货号： bs-3954R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-3954R-Cy7
- 英文名称
- Anti-STXBP1/Munc18-1/Cy7
- 中文名称
- Cy7标记的神经突触前膜胞内蛋白18抗体
- 别 名
- Munc 18 1; Munc 18a; NSec1; p67; Rb sec1; STXBP1; Syntaxin binding protein 1; Unc 18 homolog; Unc 18A; Unc18 1; STXB1_HUMAN; Syntaxin-binding protein 1; MUNC18-1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 神经生物学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Horse,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 68kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Munc18 (2-45aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
Function:
May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
Subunit:
Binds SYTL4. Interacts with STX1A.
Subcellular Location:
Cytoplasm. Membrane; Peripheral membrane protein.
Tissue Specificity:
Brain and spinal cord. Highly enriched in axons.
DISEASE:
Defects in STXBP1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.
Similarity:
Belongs to the STXBP/unc-18/SEC1 family.
Database links:Entrez Gene: 6812Human
Entrez Gene: 20910Mouse
Entrez Gene: 25558Rat
Entrez Gene: 404293Chicken
Omim: 602926Human
SwissProt: Q6R748Chicken
SwissProt: P61764Human
SwissProt: O08599Mouse
SwissProt: P61765Rat
Unigene: 288229Human
Unigene: 278865Mouse
Unigene: 80843Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.