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货号： bs-4051R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-4051R-Cy7
- 英文名称
- Anti-Nectin 4/Cy7
- 中文名称
- Cy7标记的脊髓灰质炎病毒受体相关蛋白4抗体
- 别 名
- Ig superfamily receptor LNIR; Nectin 4; poliovirus receptor-related 4; PRR4; poliovirus receptor related 4.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 细菌及病毒 细胞表面分子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 53kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Nectin-4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
Subunit:
Self-associates. Interacts via its Ig-like V-type domain with PVRL1/nectin-1 Ig-like V-type domain. Interacts via its C-terminus with MLLT4. Binds to Measles virus protein H and acts as a receptor for this virus.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein (Potential). Cell junction, adherens junction. Processed poliovirus receptor-related protein 4: Secreted.
Tissue Specificity:
Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.
Similarity:
Belongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Database links:Entrez Gene: 81607Human
Entrez Gene: 71740Mouse
Entrez Gene: 498281Rat
Omim: 609607Human
SwissProt: Q5E9Z9Cow
SwissProt: Q96NY8Human
SwissProt: Q8R007Mouse
Unigene: 492490Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.